Diferencia entre revisiones de «Enfermedad de los Ojos Azules»
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| Línea 27: | Línea 27: | ||
==Características== | ==Características== | ||
| − | + | Domestic hosts include dogs, cats and pigs and wild hosts include rabbits, rats, ferral cats and dogs and [http://en.wikipedia.org/wiki/Peccary Peccary's]. The '''virus only shows clinical signs in pigs''' but antibodies can be detected in rabbits, rats, dogs and cats. | |
| − | + | The disease affects '''all age ranges of pigs''' and also causes '''reproductive disorder in the boar'''. | |
==Signos Clínicos== | ==Signos Clínicos== | ||
| − | + | '''Generally''' pigs suffer from '''anorexia''', weight loss, '''reluctance to move''', dehydration, periorbital and conjunctival swelling (chemosis) and '''purulent/serous ocular discharge''' and '''corneal opacity'''. The virus also causes neurological signs including tetraparesis, opisthotonus, dysmetria, proprioceptive disorders, '''tremors''', nystagmus | |
| + | mydriasis, blindness, decreased or absent menace response and respiratory signs; tachypnea, dyspnea, and '''open mouthed breathing'''. | ||
| − | + | In addition the virus affects different age group and sexes in the following ways: | |
| − | ''' | + | '''Piglets and Weaners:''' |
| − | + | Piglet and weaners suffer from prostration, hind limb '''stiffness''', generalised weakness, muscle fasciculations, retarded growth, depression, excitation, head pressing, circling, '''hyperaesthesia''', abnormal behaviour/'''aggression''' and '''coma'''. In piglets the disease also causes '''changes in hair coat''' (dull/rough), '''ocular erosions''', '''enlarged distended bladder''' and '''constipation/reduction in faeces or diarrhoea'''. | |
| − | ''' | + | '''Sows:''' |
| − | + | In sows the disease causes '''infertility''', reproductive failures, '''embryonic mortality''', '''return to oestrus in the first third of gestation''' and '''stillbirths, small litters''' and '''mummification in late gestation'''. | |
| − | ''' | + | '''Boars:''' |
| − | + | In the boar it causes '''infertility, lack of libido, haemospermia''', and '''orchitis with epidydimitis''' and swelling of the genitals. | |
==Epidemiología== | ==Epidemiología== | ||
| − | + | BEPV is spread via direct contact, fomites and possibly birds. The virus can be found in the '''axon of neurons''' from its original site of replication, which is thought to be the '''nasal mucosa and tonsils'''. It is also found in tissues such as lung, liver, spleen, kidney, lymph node, heart and testis; suggesting that the virus is spread haematogenously. | |
| − | + | The virus has cytopathic effects on these tissues as causes individual rounded cells, cytoplasmic vacuoles, and syncytium formation, dead cells detachment, which leave small plaques. Viral inclusion bodies can be seen in some cells. | |
==Distribución== | ==Distribución== | ||
| − | + | The disease appears restricted to '''Central Mexico and its states'''. | |
==Diagnóstico== | ==Diagnóstico== | ||
| − | + | ''Blue-eyed disease'' can be diagnosed by a combination of history, above clinical signs, serology, lesions and virus isolation. | |
| − | + | A week after infection a serological response can be seen using a '''virus neutralization test''' and 2 weeks later with a [[Agglutination|'''haematoglutination inhibition test''']]. | |
| − | + | The diagnosis can be '''confirmed''' using '''virus isolation''' on PK15 or primary pig kidney, using samples from infected tonsils, brain or lung. | |
| − | + | During infection '''[[lymphocytosis]]''' and '''[[monocytosis]]''' may be observed. | |
| − | + | On '''post mortem''' all age ranges have corneal opacity which is mainly unilateral. Piglets show evidence of mild pneumonia, distended bladder and stomach, fibrin strands in the peritoneal cavity and '''congestion in the brain'''. Growers show kidney and '''pericardial haemorrhages''' as well as brain congestion. '''Necrosis of the seminiferous tubules''' and rupture of the epidydimis walls and subsequent abscess and granuloma formation has been documented in boars. | |
| − | ''' | + | '''Differential diagnoses''': [[Porcine Reproductive and Respiratory Syndrome|''PRRS'']] and [[Suid Herpesvirus 1|''Pseudorabies'']]. |
==Tratamiento== | ==Tratamiento== | ||
| − | + | There is '''no treatment''' for ''Blue eye disease''. '''Supportive medication''' for respiratory and inflammatory disease should be administered. | |
| − | + | Euthanasia may be necessary for ataxic pigs. | |
==Control== | ==Control== | ||
| − | + | The disease is '''self limiting''' and closed herds will have sporadic outbreaks of the disease once a herd is infected. There is '''no approved vaccine''' for the control of blue eye disease but killed-virus vaccine has been shown to be effective <ref name="Stephano et al., 1992"> Stephano, H.A., Olvera, M.J., Garcia, V.P., Ramirez, M.H., Cordoba, D.J. (1992). '''Eficacia de una vacuna inactivada para la prevencion de la infeccion por el paramyxovirus de ojo azul'''. ''Mem 27th Congr Assoc Mex Vet Esp Cerdos. Acapulco, Gro''., 24-28.</ref>. Preventative health programmes to prevent the spread of the disease are the most effective methods of control. Eliminating blue eye disease from affected herds can be achieved by '''closing the herd, running an all-in/all-out systems''', and following good '''washing and disinfecting protocols'''. | |
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{{Learning | {{Learning | ||
| − | |flashcards = [[Flashcards | + | |flashcards = [[Blue Eye Disease Flashcards]] |
}} | }} | ||
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==Referencias== | ==Referencias== | ||
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|date = 9 September 2011}} | |date = 9 September 2011}} | ||
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[[Categoría:Enfermedades de Cerdos]] | [[Categoría:Enfermedades de Cerdos]] | ||
| − | [[ | + | [[Category:Paramyxoviridae]] |
| + | [[category:Neurological Diseases - Pig]][[Category:Respiratory Diseases - Pig]][[Category:Reproductive Diseases - Pig]] | ||
| + | [[Category:CABI Expert Review Completed]][[Category:CABI AHPC Pages]] | ||
Revisión del 08:25 24 abr 2012
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También conocdia como: Ojo Azul — BE — Síndrome del Ojo Azul — Enfermedad del Ojo Azul por Paramixovirus Porcino — PPBED — Paramixovirus — Rubulavirus Porcino — Paramixovirus del Ojo Azul — BEP — BEPV
| Scientific Classification | |
|---|---|
| Kingdom | Virus |
| Order | Mononegavirales |
| Family | Paramyxoviridae |
| Genus | Rubulavirus |
| Species | Blue-eye paramyxovirus |
Introducción
La enfermedad del ojo azul es causada por el paramixovirus del ojo azul (BEPV). Es un virus ARN de cadena única de polaridad negativa (ssRNA). Está estrechamente relacionado con el virus de la parotiditis y el virus simio 5 y está clasificado en la familia Paramyxoviridae. El virus tiene 135-148nm por 257-360nm, posee una densidad de flotación en gradientes de sacarosa de 1,21 g/ml y se considera polimórfico (pero principalmente es esférico). El BEPV está envuelto por proyecciones de superficie y la cubierta de la nucleocápside contiene hemaglutinina-neuraminidasa y fusión de las proteínas de la matriz. El virus está formado por seis proteínas estructurales y es resistente a actinomicina D y sensible a cloroformo, formalina y beta-propiolactona.
Produce síntomas nerviosos, reproductivos y respiratorios en su hospedador doméstico, el cerdo. La enfermedad no se considera una zoonosis.
Características
Domestic hosts include dogs, cats and pigs and wild hosts include rabbits, rats, ferral cats and dogs and Peccary's. The virus only shows clinical signs in pigs but antibodies can be detected in rabbits, rats, dogs and cats.
The disease affects all age ranges of pigs and also causes reproductive disorder in the boar.
Signos Clínicos
Generally pigs suffer from anorexia, weight loss, reluctance to move, dehydration, periorbital and conjunctival swelling (chemosis) and purulent/serous ocular discharge and corneal opacity. The virus also causes neurological signs including tetraparesis, opisthotonus, dysmetria, proprioceptive disorders, tremors, nystagmus mydriasis, blindness, decreased or absent menace response and respiratory signs; tachypnea, dyspnea, and open mouthed breathing.
In addition the virus affects different age group and sexes in the following ways:
Piglets and Weaners:
Piglet and weaners suffer from prostration, hind limb stiffness, generalised weakness, muscle fasciculations, retarded growth, depression, excitation, head pressing, circling, hyperaesthesia, abnormal behaviour/aggression and coma. In piglets the disease also causes changes in hair coat (dull/rough), ocular erosions, enlarged distended bladder and constipation/reduction in faeces or diarrhoea.
Sows:
In sows the disease causes infertility, reproductive failures, embryonic mortality, return to oestrus in the first third of gestation and stillbirths, small litters and mummification in late gestation.
Boars:
In the boar it causes infertility, lack of libido, haemospermia, and orchitis with epidydimitis and swelling of the genitals.
Epidemiología
BEPV is spread via direct contact, fomites and possibly birds. The virus can be found in the axon of neurons from its original site of replication, which is thought to be the nasal mucosa and tonsils. It is also found in tissues such as lung, liver, spleen, kidney, lymph node, heart and testis; suggesting that the virus is spread haematogenously.
The virus has cytopathic effects on these tissues as causes individual rounded cells, cytoplasmic vacuoles, and syncytium formation, dead cells detachment, which leave small plaques. Viral inclusion bodies can be seen in some cells.
Distribución
The disease appears restricted to Central Mexico and its states.
Diagnóstico
Blue-eyed disease can be diagnosed by a combination of history, above clinical signs, serology, lesions and virus isolation.
A week after infection a serological response can be seen using a virus neutralization test and 2 weeks later with a haematoglutination inhibition test.
The diagnosis can be confirmed using virus isolation on PK15 or primary pig kidney, using samples from infected tonsils, brain or lung.
During infection lymphocytosis and monocytosis may be observed.
On post mortem all age ranges have corneal opacity which is mainly unilateral. Piglets show evidence of mild pneumonia, distended bladder and stomach, fibrin strands in the peritoneal cavity and congestion in the brain. Growers show kidney and pericardial haemorrhages as well as brain congestion. Necrosis of the seminiferous tubules and rupture of the epidydimis walls and subsequent abscess and granuloma formation has been documented in boars.
Differential diagnoses: PRRS and Pseudorabies.
Tratamiento
There is no treatment for Blue eye disease. Supportive medication for respiratory and inflammatory disease should be administered.
Euthanasia may be necessary for ataxic pigs.
Control
The disease is self limiting and closed herds will have sporadic outbreaks of the disease once a herd is infected. There is no approved vaccine for the control of blue eye disease but killed-virus vaccine has been shown to be effective [1]. Preventative health programmes to prevent the spread of the disease are the most effective methods of control. Eliminating blue eye disease from affected herds can be achieved by closing the herd, running an all-in/all-out systems, and following good washing and disinfecting protocols.
Referencias
- ↑ Stephano, H.A., Olvera, M.J., Garcia, V.P., Ramirez, M.H., Cordoba, D.J. (1992). Eficacia de una vacuna inactivada para la prevencion de la infeccion por el paramyxovirus de ojo azul. Mem 27th Congr Assoc Mex Vet Esp Cerdos. Acapulco, Gro., 24-28.
| Enfermedad de los Ojos Azules Entorno de Enseñanza Virtual | |
|---|---|
 Comprobar tus conocimientos utilizando preguntas de tipo Flashcard |
Blue Eye Disease Flashcards |
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Este artículo fue originalmente de The Animal Health & Production Compendium (AHPC) publicado en el web por CABI. Hoja(s) de datos utilizados: blue eye disease and blue eye paramyxovirus el 11 June 2011 |
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Este artículo ha sido revisado por el experto Dr Mandy Nevel Fecha de revisión: 9 September 2011 |